Tel, a frequent target of leukemic translocations, induces cellular aggregation and influences expression of extracellular matrix components

Abstract

Tel (ETV6) is an ETS transcription factor that is found fused to a variety of tyrosine kinases and transcription factors in lymphoid and myeloid leukemias and in fibrosarcoma and mesoblastic nephroma. It contains two functional domains, a pointed (PNT) protein interaction domain and a DNA binding domain (DBD).