Tek Doz Preemptif İntravenöz Deksketoprofen Trometamol ve İbuprofen'in Üçüncü Molar Cerrahisi Sonrası Ağrı ve Ödem Kontrolü Üzerine Etkileri: Prospektif, Randomize, Çift Kör ve Klinik Bir Çalışma

Abstract

Objective: This comparative study aims to investigate the single-dose preemptive effects of intravenous (IV) dexketoprofen trometamol, ibuprofen for pain and edema control in mandibular wisdom teeth surgery. Material and Methods: In this study, 75 patients were randomly divided into 3 groups. Group 1 received IV ibuprofen 60 min before surgery; Group 2 received IV dexketoprofen trometamol 60 min before surgery; Group 3 received IV placebo (100 cc saline) 60 min before surgery. The pain and facial swelling were evaluated. Postoperative pain was recorded with a Visual Analog Scale (VAS) during 24 h. The total recovery acetaminophen intake dose was recorded in the first 24 h. Also, a 3D surface imaging device was used in the evaluation of swelling. Results: There was no statistically significant difference in the pain between the ibuprofen and dexketoprofen groups. There was a statistically significant difference in the edema on the 2nd day (T1) between the ibuprofen and dexketoprofen group (p=0.010). On the 2nd day edema, the amount of edema observed in the ibuprofen group was recorded as the least. Postoperative edema and pain were higher in the placebo group than in the other groups (p<0.05). Conclusion: The findings obtained in this study suggest that the preemptive application of IV ibuprofen and dexketoprofen is effective in the control of edema and pain compared to the placebo group after third molar surgery.