Abstract
Telomeres and centromere are two essential features of all eukaryotic chromosomes. They provide function that is necessary for the stability of chromosomes. We developed a comprehensive database named TeCK, which covers a gamut of sequence and other related information about telomeric patterns, telomere repeat sequences, centromere sequences and centromeric patterns present in chromosomes. It also contains information about telomerase ribo-nucleoprotein complexes, centromere binding protein and centromere DNA-binding protein complexes. The database also includes a collection of all kinetochore-associated proteins including inner, outer and central kinetochore proteins. The database can be searched using a user-friendly web interface. http://www.bioinfosastra.com/services/teck/index.html.
Highlights
Telomeres [1] are a series of repeated DNA sequences located at the end of chromosomes, with strand asymmetry in GC content, resulting in one G-rich strand and one Crich strand
They serve to assure that a chromosome is replicated properly during cell division
Centromeres [3] are DNA sequences contained in the heterochromatin, responsible for the segregation of each chromosome into daughter cells during cell division
Summary
Telomeres [1] are a series of repeated DNA sequences located at the end of chromosomes, with strand asymmetry in GC content, resulting in one G-rich strand and one Crich strand. Background: Telomeres [1] are a series of repeated DNA sequences located at the end of chromosomes, with strand asymmetry in GC content, resulting in one G-rich strand and one Crich strand. They serve to assure that a chromosome is replicated properly during cell division. [2] Telomerase is an enzyme that adds specific DNA sequence repeats, (“TTAGGG” in all vertebrates) to the 3’ end of DNA strands, in the telomere regions at the ends of chromosomes, preventing it from getting shorter.
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