Abstract
The article presents the results of experimental research on the development of a formulation and technology for the industrial production of kumis drink enriched with an iodine-glycoside complex, which is a source of molecular iodine with antioxidant activity. Study of the iodine level in patients with tuberculosis showed the following results: iodine deficiency was diagnosed in 86,7% of the total number of examined patients - the median ioduria in this group of patients ranged from 20 ?g/l to 99 ?g/l. The article describes a technology of production of kumis drink enriched with iodine-glycoside complex, including following operations: acceptance and preparation of raw materials; normalization and preparation of the mixture; pasteurization, homogenization, cooling and insertion of "iodine-glycoside"; preparation of the fermentation culture; fermentation and souring, bottling, maturation of the drink; packaging, labeling and cooling. It also includes the results of evaluating the organoleptic indicators of kumis drink - consistency, taste, color, smell and appearance, as well as the physical and chemical parameters: weight fraction of fat, protein, dry fat-free substances; the volume of settled whey, antioxidant balance in respiratory pathology by activating the KEAP1 /Nrf2 /ARE redox-sensitive system inducing the gene expression that control the endogenous antioxidants synthesis. Binary complex (kumis drink + molecular iodine) is considered here as a non-pharmacological pathogenetic agent. The technological process of the production of a functional product with anti-tuberculosis activity ensured the preservation of the physical and chemical parameters of the kumis drink, reducing the titratable acidity to 44,8% in the iodine-enriched drink against 57,6% in the control sample. The author elaborates on mechanisms of the participation of the “iodine-glycoside complex” and low-molecular organic substances, in particular, the amino acids of the kumis drink, in the regulation of pro-, with pleiotropic properties for the treatment and prevention of tuberculosis.
Highlights
Известно, что уровень обеспеченности йодом организма человека оценивается по содержанию данного струмотропного микроэлемента (I–) в моче
The article presents the results of experimental research on the development of a formulation and technology for the industrial production of kumis drink enriched with an iodine-glycoside complex, which is a source of molecular iodine with antioxidant activity
Study of the iodine level in patients with tuberculosis showed the following results: iodine deficiency was diagnosed in 86,7% of the total number of examined patients - the median ioduria in this group of patients ranged from 20 μg/l to 99 μg/l
Summary
Технология производства Chebotarev S.N., Maksyutov R.R. Technology of production of kumis кумысного напитка, обогащенного йод-гликозидным комплексом // drink enriched with iodine-glycoside complex. Уровень йода в моче определяли арсенитно-цериевым методом [1]. У 75 больных медиана йодурии составила менее 20 мкг/л (тяжёлый дефицит), у 25 – выявлен дефицит средней тяжести – от 20 до 49 мкг/л; а у 30 пациентов дефицит легкой степени – 50–99 мкг/л [1]. Исследования ряда авторов позволили выявить широкий спектр экстратиреоидных эффектов молекулярного йода [5]. Негормональный йод в окисленной форме действует как донор электронов, нейтрализуя активные формы кислорода. Один из механизмов реализации антиоксидантного эффекта молекулярного йода – активация редокс-чувствительной системы Кеар1/Nrf2/ARE [6]. В своей молекулярной форме йод действует как антиоксидант при приеме внутрь в концентрациях выше 1 мг/сут [3]. Цель работы – разработка состава, технологии производства и товароведная оценка йодобогащенного кумысного напитка для профилактики и лечения туберкулеза
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