Abstract
A method of preparing tablets called liquisolid technique is currently emerging. In these formulations, an important role is played by porous carriers, which are the basic building blocks of liquisolid systems (LSSs). The most common are microcrystalline cellulose (MCC), magnesium aluminometasilicates, silica aerogels, mesoporous silicates, clays, etc. In this study, magnesium aluminometasilicate is used to prepare modified LSS formulations with plant extracts as model drugs dissolved in water (W) or ethanol (E). The modification involves drying tablets in a microwave (MW) and hot air dryer (HA) for a specified period. Powder blends and tablets were evaluated for physical properties, and their antioxidant activity (AA) was measured in a modified dissolution by ferric reducing antioxidant power assay (FRAP). PLS and ANOVA were used to compare tablets properties depending on the composition and technology. The experiment is based on a previous one, in which the plant extracts were processed into tablets using a similar method. Therefore, extending the study to include more plants and the robust statistical evaluation and comparison of the products was a procedure to justify the suitability of the presented method for a wide range of liquid plant extracts. As a result, we obtained tablets with excellent physical properties, including a short disintegration and dissolution, which is problematic in tableted extracts.
Highlights
The growing interest in natural medicines is reflected in the research and development of dosage forms
An original technology based on the liquisolid system (LSS) using a porous carrier and hydrophilic solvents, subsequently evaporated from the compacts, proved promising for plant extracts with antioxidant activity (AA)
This study showed a decrease in the crystallinity of clonazepam in a LSS, which was reflected in an improvement in its solubility [15]
Summary
The growing interest in natural medicines is reflected in the research and development of dosage forms. Liquid natural extracts are usually hydrophilic and chemically and microbially unstable. Their processing into solid dosage forms is promising. The processing of larger amounts of dried extracts is limited due to their poor flowing properties and compressibility. An original technology based on the liquisolid system (LSS) using a porous carrier and hydrophilic solvents, subsequently evaporated from the compacts, proved promising for plant extracts with antioxidant activity (AA). The work demonstrated the technological possibilities of preparation on a limited number of model extracts. A more comprehensive study of whether the technology itself affects AA and whether AA was retained concerning different plant species was necessary due to significant differences in the composition of each extract (Table 1) [1]. The first work was focused mainly on plant materials; this work focuses on the theoretical justification of the porous material used
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