Abstract
Introduction. This study deals with the problem of similarity of the principles and approaches of drug technologies in the medieval manuscript “Antidotarium Nicolai” by Nicholas of Salerno with modern pharmaceutical technologies.The aim of study is a textual investigation of “Antidotarium Nicolai”, a detailed research of the content of the manuscript, recipes and technologies for making medicines.Materials and methods. In order to achieve this goal, eighty-five recipes of “Antidotarium Nicolai” have been identified, systematized and analyzed in a documentary translation from medieval French. An interdisciplinary study of the content of the manuscript was carried out with the help of factor analysis of the historical source and modern scientific literature.Results and discussion. Having described the content and aspects of the prescriptions of “Antidotarium Nicolai”, the authors note the similarity of the technologies of drugs and galenical preparations with modern pharmaceutical technology, in particular, with the technology of pharmacy production. In “Antidotarium Nicolai” it is stated that preparations based on herbal medicinal raw materials may be second-line therapy agents for completing treatment after the application of basic pharmacological preparations.Conclusion. The results of this work reveal the potential for the use of herbal medicines in the conditions of modern evidence-based medicine, in particular, in the organization of long-term treatment and secondary prevention of chronic diseases in patients who need to maintain their ability to work, and provide them with a sufficiently high level of quality of life. A detailed translation of the full text of the manuscript, the analysis of its content in accordance with the requirements of rational pharmacotherapy and phytotherapy, further favors to identify the prospects for the development of new drugs, multi-component in their chemical composition with a wide range of therapeutic effects.
Highlights
This study deals with the problem of similarity of the principles and approaches of drug technologies in the medieval manuscript “Antidotarium Nicolai” by Nicholas of Salerno with modern pharmaceutical technologies
The evidence of this interpenetration was the manuscript “Antidotarium Nicolai” by master Nicholas of Salerno, known as Nicolaus Salernitanus. This manuscript was the main pharmacopeia of the entire medieval world [1]. The relevance of this worklies in studying the technologies of manufacturing drugs according to “Antidotarium Nicolai” recipes, based on the prescriptions translated into Russian, as well as the study of their practical potential for modern health care
The hypothesis of the study is the thesis of the similarity of the principles and approaches to the production of medicines according to the prescription formulas of “Antidotarium Nicolai”, created by master Nicholas of Salerno, with modern pharmaceutical technologies
Summary
This study deals with the problem of similarity of the principles and approaches of drug technologies in the medieval manuscript “Antidotarium Nicolai” by Nicholas of Salerno with modern pharmaceutical technologies. A vivid example of that was Medieval Europe, where a kind of fusion of medical knowledge, accumulated by the West and the East, occurred. The evidence of this interpenetration was the manuscript “Antidotarium Nicolai” by master Nicholas of Salerno, known as Nicolaus Salernitanus. By means of studying the prescriptions of the manuscript, our AIM is to compare the medieval technology of manufacturing medicines and galenical preparations with modern principles of pharmaceutical technology
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