Abstract
The development of fluorination methodologies has been bolstered by the use of F-18 labeled ligands in positron emission tomography (PET). Fluorination chemistry has taken great strides developing new and efficient aliphatic and aromatic fluorination methods for the incorporation of F-19 and F-18. Fluorinated compounds are used extensively in medicine and drug design as they have been developed to treat a range of disorders and conditions such as cancer, CNS, antiviral, anesthetics, infection and inflammation. Methods for the installation of fluorine have improved dramatically over the last ten years, aromatic fluorination whether nucleophilic or electrophilic aromatic substitution remains challenging. The importance of the nitro leaving group for nucleophilic aromatic fluorine substitution (fluorodenitrations), the need for late stage selective ipso-substitution of the nitro group, and subsequent fluorination of nitroarenes will be discussed.
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