Abstract
DNA adducts are formed from the covalent reaction of electrophilic molecules to a variety of nucleophilic groups in DNA strands. They could be used as biomarkers for genotoxicity. The formation of DNA adducts caused by toxic chemicals is a critical initiator in the process of gene mutation, developmental malformation and tumor. The development of fast, sensitive and accurate detection technologies and methodologies is the key to understand and study the adverse health effects of DNA adducts. At present, analytical technologies for the detection of DNA adducts mainly include 32P post-labeling, immunoassay, immuno-capillary electrophoresis-laser induced fluorescence, DNA sequencing, and Chromatography-mass spectrometry. In this article, the applications and development prospects of these techniques and methods in DNA adducts analysis are briefly reviewed and discussed.
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