Abstract
The optimum composition of temperature-sensitive liposomes (TSLs) has been chosen and a method of doxorubicin loading in TSLs by ammonium ion gradient has been developed. The TSL-encapsulated doxorubicin was lyophilized for better stabilization with 4.0% sucrose added as a cryoprotective agent. A method based on spectrophotometry at 252 nm is proposed for the determination of oxorubicin concentration in TSLs. It is established that TSLs encapsulate 89.5 ± 3.5% of doxorubicin. The particle size of the vesicles is 165 ± 10 nm. The proposed TSL doxorubicin formulation possesses selective action, shows higher efficiency and lower toxicity in comparison to the traditional doxorubicin, and can be recommended for use in the chemo-thermotherapy of solid tumors.
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