Abstract
То elaborate the composition of the suppositories with riboxiniirn we have studied physical and chemical, and structural and mechanical characteristics of different bases. Witepsol-H15 was chosen as a preferable base. We have carried out the quality estimation of the developed suppositories in accordance with regulatory documentation. The analysis methods offered are validated and proved to be specific, right and precise. The relative error of analysis is equal to ±0.98%. Supposito-ries with riboxinum at dose 15 mg/kg shows signified hepatoprotective action at white rats with experimental acute toxic hepatitis evoked by carbon tetrachloride injection, which ex-ceeds the similar pills effect
Highlights
У приготовленных суппозиториев оценивали: внешний вид, форму, однородность, среднюю массу
Все свечи имели правильную и одинаковую форму
6. Для количественного определения рибоксина в суппозиториях разработано спектрометрическое определение его в воде при длине волны 249 нм
Summary
У приготовленных суппозиториев оценивали: внешний вид, форму, однородность, среднюю массу. Результаты высвобождения рибоксина из суппозиториев, приготовленных на различных основах, приведены в таблице 1. Таблица 1 – Результаты высвобождения рибоксина из исследуемых основ (n=3)
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