Abstract
The genus Mikania (Asteraceae) comprises about 450 species of these, 203 are found in Brazil and present several chemical and biological activities. Considering the variety of species and their therapeutic properties, the present study aimed to perform technological prospecting of this genus, since this approach aims to contribute to technological, scientific and innovation research. For this purpose, the patent documents were analyzed, regarding the applicant countries, year of filing and the international classification of patents of the genus Mikania. The search was conducted in the databases World Intellectual Property Organization (WIPO), European Patent Office (EPO) and the National Institute of Industrial Property (INPI) in October 2020, using the descriptor “Mikania”; present in the title and/or abstract in addition, documents that included medicinal approaches were selected. Thus, taking into consideration the filing countries, Japan, Brazil and the United States led the patent deposits, with the first document filed in 1991 and the largest number of applications in the years 2000 and 2010. The data concerning the international patent classification are concentrated in subclass A61K, which deals with preparations for medical, dental or hygienic purposes. These results demonstrated the therapeutic and technological potential of the Mikania species and thus which can be evidenced the potential of this study.
Highlights
Mikania Willd. is a genus belonging to the family Asteraceae (Compositeae) and largest representative of the tribe Eupatorieae, comprising about 450 species (Coutinho, Gonçalves, & Marcucci, 2020; Honório, Quaresma, Oliveira, & Loiola, 2019)
After analyzing the patents found and including only those with a medicinal approach, 34 patents were selected for this technological prospection study (WIPO - 21 patents; European Patent Office (EPO) - 10 patents; and Instituto Nacional da Propriedade Industrial (INPI) - 03 patents). 3.1 Analysis of the World Intellectual Property Organization (WIPO) database data
Antirust stressing agent derived from the natural product that accelerates the improvement activities of the Antioxidant Response Element (ARE) in a path Erythroid-2 Nrf2/ARE related nuclear factor participating in the oxidative stress, inducing the expression of an antioxidative enzyme to mitigate the oxidative stress
Summary
Mikania Willd. is a genus belonging to the family Asteraceae (Compositeae) and largest representative of the tribe Eupatorieae, comprising about 450 species (Coutinho, Gonçalves, & Marcucci, 2020; Honório, Quaresma, Oliveira, & Loiola, 2019). Is a genus belonging to the family Asteraceae (Compositeae) and largest representative of the tribe Eupatorieae, comprising about 450 species (Coutinho, Gonçalves, & Marcucci, 2020; Honório, Quaresma, Oliveira, & Loiola, 2019). Some secondary metabolites that present pharmacological activities have already been identified in several parts of Mikania. Among the main chemical classes present in this genus, the following stand out coumarins and derivatives, sesquiterpenes, sesquiterpene lactones, diterpenes, phytosterols/terpenoids and flavonoids (Rufatto, Gower, Schwambach, & Moura, 2012). Pharmacological studies show that Mikania species have activities in the respiratory tract, anti-inflammatory, hypoglycemic, antioxidant, antiallergic, analgesic (Coutinho et al, 2020; Silva et al, 2018). The proof of the therapeutic potential of the genus facilitates research strategies and investigation of applicability in the areas of innovation and biotechnology. The survey of patents and publications enables the direction of knowledge for production and technological, scientific and economic development, in addition to issues that facilitate decision making (Correia, Júnior, Spósito, & Pungartnik, 2020; Pires, Ribeiro, & Quintella, 2020)
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