Abstract

Current consensus guidelines of the AHA and ESC, uniformly recommend either type of prosthetic valve for patients aged 60 to 70 years and mechanical prosthesis for patients aged less than 60 years

Highlights

  • Current consensus guidelines of the AHA and ESC, uniformly recommend either type of prosthetic valve for patients aged 60 to 70 years and mechanical prosthesis for patients aged less than 60 years. [1,2,3,4] These recommendations are based on the results of 4 randomized controlled trials that demonstrated no significant difference in late survival. [2,3,4,5,6] Two of these trials compared mechanical and bioprosthetic valve models implanted in 1970s and 1980s. [5,6,7] The other 2 trials included patients undergoing aortic valve replacement

  • Valve replacement in young adults entails a choice between a mechanical prosthesis with risks of anticoagulation-related bleeding/thrombosis versus bioprosthesis necessitating eventual reoperation

  • Patients who do not respond within 48-72 hours should be referred for surgery because these patients may have tissue ingrowth obstructing the prosthetic valve (Panus formation) and usually do not respond to continued thrombolytic treatment

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Summary

Introduction

Current consensus guidelines of the AHA and ESC, uniformly recommend either type of prosthetic valve for patients aged 60 to 70 years and mechanical prosthesis for patients aged less than 60 years. [1,2,3,4] These recommendations are based on the results of 4 randomized controlled trials that demonstrated no significant difference in late survival. [2,3,4,5,6] Two of these trials compared mechanical and bioprosthetic valve models implanted in 1970s and 1980s. [5,6,7] The other 2 trials included patients undergoing aortic valve replacement. Current consensus guidelines of the AHA and ESC, uniformly recommend either type of prosthetic valve for patients aged 60 to 70 years and mechanical prosthesis for patients aged less than 60 years. [5,6,7] The other 2 trials included patients undergoing aortic valve replacement.

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Conclusion
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