Abstract
Scorpionate ligands have played a crucial role in the development of technetium chemistry and, recently, they have also fueled important advancements in the discovery of novel diagnostic imaging agents based on the γ-emitting radionuclide technetium-99m. The purpose of this short review is to provide an illustration of the most general and relevant results in this field, however without being concerned with the details of the analytical features of the various compounds. Thus, emphasis will be given to the description of the general features of technetium complexes with scorpionate ligands including coordination modes, structural properties and an elementary bonding description. Similarly, the most relevant examples of technetium-99m radiopharmaceuticals derived from scorpionate ligands and their potential interest for nuclear imaging will be summarized.
Highlights
Tridentate N,N,N-donor ligands hydrotris(pyrazolyl)borates and tris(pyrazolyl)methanes form a class of versatile tripodal ligands combining a central, tetrahedral boron atom with a variable number (n = 2–4) of azolyl rings
Due to the fundamental role played by the nuclear isomer technetium-99m in diagnostic nuclear medicine, these ligands have been widely studied for the development of new diagnostic radiopharmaceuticals as imaging agents for different biological targets
Major recognition should be given to the research group of Santos at the Technological and Nuclear Institute in Lisbon, which carried out a multitude of excellent studies in this field, in the synthesis of scorpionate complexes with technetium in low oxidation states [5,9,10]
Summary
In this respect, major recognition should be given to the research group of Santos at the Technological and Nuclear Institute in Lisbon, which carried out a multitude of excellent studies in this field, in the synthesis of scorpionate complexes with technetium in low oxidation states [5,9,10]. A reconsideration of the potential clinical utility of 99m Tc tracers that have been set aside because of the past emphasis on PET agents In this short review, an illustration of the most important classes of technetium scorpionate complexes will be overviewed with special focus on those compounds that have been prepared at no-carrier added level with the radioisotope 99m Tc
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