Abstract
Small cationic peptides radiolabeled with technetium-99m are new tools for the scintigraphic imaging of bacterial infections. Due to the specific binding of these peptides to the bacterial membrane, they accumulate at sites of infection but not in sterile inflammatory lesions, This article describes the characteristics of these peptides and the available labeling methods to tag these compounds with technetium-99m, the radionuclide of choice fot future human use. Results for the mapping of experimental infections in mice and monitoring the efficacy of antibacterial therapy are also presented. Technetium-99m-labeled cationic antimicrobial peptides, thus, are promising candidates for the scintigraphic visualization of sites of bacterial infection in patients.
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