Abstract
Team building and leadership in the successful implementation of automation for high throughput screening
Highlights
High throughput screening, perhaps more than any other laboratory automation task, illustrates the need for a diverse set of skills that can be brought together to solve a critical need in the pharmaceutical industry, namely the rapid and efficient discovery of new pharmacophores against a diverse set of disease targets
This paper shows why high throughput screening programmes have become a fast growing area in which laboratory automation is playing a critical role
The unique philosophical and technical problems associated with high throughput screening are examined, and the paper explains how a team-based approach to solving these automation problems has become crucial in the successful implementation of these tasks
Summary
Perhaps more than any other laboratory automation task, illustrates the need for a diverse set of skills that can be brought together to solve a critical need in the pharmaceutical industry, namely the rapid and efficient discovery of new pharmacophores against a diverse set of disease targets. Hook Team building and leadership in the successful implementation of automation for high throughput screening drugs or rational design criteria These factors are leading to the shortening of the discovery cycle and a movement away from ’metoo’ compounds, but this pressure has resulted in new obstacles for high throughput screening. These are the numbers, chemical diversity of compound libraries, cost and time (how many compounds should be screened to discover with the highest probability desired, all potentially novel chemotypes, how diverse does a company’s compound collection have to be to cover all possible pharmacophores for a given target; how fast can the library be screened; can this be done at a low enough cost to be economically feasible?). These questions are at the heart of state-of-the-art high throughput screening programmes, and have serious implications about how a successful HTS programme can be implemented and have a significant impact on the design of automated HTS systems
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