Abstract
Immune responses can be modulated via associative learning paradigms. We have established a model of behaviorally conditioned suppression of immune functions in rodents and healthy humans, employing the immunosuppressant cyclosporine A (CsA) as an unconditioned stimulus, by demonstrating a behaviorally conditioned suppression of T cell proliferation and cytokine production. This learned immune response is mediated centrally via the insular cortex and the amygdala as well as on the efferent arm via the splenic nerve, through noradrenaline and adrenoceptor-dependent mechanisms and is sufficient to prolong heart allograft survival in rats.
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