Abstract
ObjectivesTea is supposed to have chemopreventive effect against various cancers. However, the protective role of tea in prostate cancer is still controversial. The aim of this study is to elucidate the association between tea consumption and prostate cancer risk by meta-analysis.MethodsA total of 21 published articles were retrieved via both computerized searches and review of references. Estimates of OR/RR for highest versus non/lowest tea consumption levels were pooled on the basis of random effect model or fixed effect model as appropriate. Stratified analyses on tea type, population and study design were also conducted.ResultsNo statistical significance was detected between tea consumption and prostate cancer risk in meta-analysis of all included studies (odds ratio (OR) = 0.86, 95% CI (0.69-1.04)). Furthermore, stratified analyses on population (Asian, OR = 0.81, 95% CI (0.55-1.08); non-Asian, OR = 0.89, 95% CI (0.72-1.07)) and tea type (green tea, OR = 0.79, 95% CI (0.43-1.14); black tea, OR = 0.88, 95% CI (0.73-1.02)) also yielded non-significant association. Only the case–control study subgroup demonstrated a borderline protective effect for tea consumption against prostate cancer (OR = 0.77, 95% CI (0.55-0.98)).ConclusionOur analyses did not support the conclusion that tea consumption could reduce prostate cancer risk. Further epidemiology studies are needed.
Highlights
Prostate cancer remains one of the most common cancers afflicting men today
Eligible studies should fulfill all the following inclusion criteria: (1) studies evaluating the tea consumption and prostate cancer risk; (2) the consumption of the natural green tea product, not of green tea extracts or supplements, were recorded; (3) the outcome of interest should be an incidence of prostate cancer; (4) odds ratio (OR) or relative risk (RR) estimates with corresponding 95% Confidence interval (CI) were provided
Five articles providing separate adjusted ORs for different tea types were treated as independent studies (Table 1)
Summary
Prostate cancer remains one of the most common cancers afflicting men today. It is one of the most frequently diagnosed malignancies among men in the world [1]. The etiology of this malignancy remains unclear, both hereditary and environmental components are considered to contribute to prostate carcinogenesis, with age, race, and family history being the only well-established risk factors [2]. Ecologic studies have offered substantial evidence that dietary factors may play a role in the etiology of prostate cancer [3]. Tea is generally consumed in the form of black (fermented), green (unfermented) and oolong (partially fermented), of latest published studies. We intended to provide the best available evidence as to whether tea consumption can reduce prostate cancer risk
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