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Abstract
To what extent the lineage decisions of activated CD4+ Tcells are determined by the quality of Tcell receptor (TCR) ligation is incompletely understood. Here, we show that individual Tcells expressing identical TCRs take highly variable fate decisions despite binding the same ligand. We identify a mathematical model that correctly captures this probabilistic behavior and allows one to formalize changes inTCR signal quality-due to cognate versus altered peptide ligation-as changes of lineage-specific proliferation and differentiation rates. We show that recall responses also adhere to this probabilistic framework requiring recruitment of multiple memory clones to provide reliable differentiation patterns. By extending our framework to simulate hypothetical TCRs of distinct binding strength, we reconstruct primary and secondary response patterns emerging from a polyclonal TCR repertoire insilico. Collectively, these data suggest that individual Tcells harboring distinct TCRs generate overlapping primary differentiation patterns that segregate only upon repetitive immunization.
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