Abstract
Dissociated cell cultures were prepared from human spinal cords of 7–10-week-old fetuses. After 10 weeks progressive neuronal necrosis was observed in controls whereasN /1-(2-thienyl)cyclohexyl/piperidine (TCP) enhanced the survival time of the cells. After 21 weeks the number of γ-aminobutyric acid (GABA)ergic and neuron specific enolase (NSE)-stained neurons was higher in the TCP-treated cultures than in controls. TCP appears to be a promising drug for long term survival of neurons.
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