Abstract
Background Type 2 diabetes mellitus (T2DM) has become one of the serious public health problems in China, and it affects the quality of survival of patients significantly. The long-term monitoring and early warning of T2DM and its complications should be paid attention to. Artificial diagnosis of T2DM in traditional Chinese medicine (TCM) is subjective and unrepeatable at the present stage. It is important to develop standardized collection and objective analysis methods of TCM inquiry. Therefore, we are interested in establishing syndrome recognition models. Objective The establishment of the TCM syndrome recognition model of T2DM is helpful to the syndrome diagnosis of the disease, and the clear diagnosis of the syndrome is the prerequisite for the effective treatment of the disease by TCM. At present, there are few studies on syndrome recognition models of T2DM. Therefore, based on the inquiry information of TCM, we establish a latent structure model (LSM) of T2DM syndrome in Shanghai, hoping to provide services for the health management of TCM for diabetes in the future. Methods A total of 587 effective samples of T2DM patients in Shanghai were collected. The gender, course of disease, and chronic complications were analyzed by one-way ANOVA and frequency analysis. Inquiry symptoms that could be included in the model were screened. In the study, 30 symptoms were used as observable variables to analyze the symptom information of TCM inquiry, and then, the TCM syndrome recognition model was established. Results The clinical syndromes of patients with T2DM in Shanghai were mixed with deficiency and excess. The LSM divided the pattern of the disease into qi-yin deficiency pattern, yin deficiency pattern, qi deficiency pattern, and qi stagnation pattern. These patterns were mainly located in the spleen and stomach, liver, and kidney. Conclusion The results of the syndrome classification of T2DM by LSM are basically consistent with the TCM clinical characteristics of the disease, which could reflect its main etiology and pathogenesis. The LSM of TCM inquiry syndrome diagnosis of T2DM confirmed the objectivity of TCM syndrome differentiation to some extent, and it will lay a foundation for the development of a mobile APP for TCM health management of T2DM.
Highlights
According to the International Diabetes Federation in 2019, there were 463 million diabetes patients between the ages of 20 and 79 worldwide, of which about 4.2 million died from diabetes or its complications only in 2019, accounting for 11.3% of all global deaths
Many researchers have established and explored to the standardized collection of traditional Chinese medicine (TCM) inquiry information and the exploration of objective analysis methods, which has made some progress in the objective, standardized, and procedural research of TCM inquiry
The latent structure model (LSM) proposed by Zhang [2] could analyze the information of TCM inquiry and establish a TCM syndrome recognition model. e model is the result of the multidimensional division of the population from various perspectives based on the characteristics of the data itself, which has strong objectivity and quantification
Summary
Type 2 diabetes mellitus (T2DM) has become one of the serious public health problems in China, and it affects the quality of survival of patients significantly. e long-term monitoring and early warning of T2DM and its complications should be paid attention to. It is important to develop standardized collection and objective analysis methods of TCM inquiry. Erefore, based on the inquiry information of TCM, we establish a latent structure model (LSM) of T2DM syndrome in Shanghai, hoping to provide services for the health management of TCM for diabetes in the future. 30 symptoms were used as observable variables to analyze the symptom information of TCM inquiry, and the TCM syndrome recognition model was established. E results of the syndrome classification of T2DM by LSM are basically consistent with the TCM clinical characteristics of the disease, which could reflect its main etiology and pathogenesis. E LSM of TCM inquiry syndrome diagnosis of T2DM confirmed the objectivity of TCM syndrome differentiation to some extent, and it will lay a foundation for the development of a mobile APP for TCM health management of T2DM Conclusion. e results of the syndrome classification of T2DM by LSM are basically consistent with the TCM clinical characteristics of the disease, which could reflect its main etiology and pathogenesis. e LSM of TCM inquiry syndrome diagnosis of T2DM confirmed the objectivity of TCM syndrome differentiation to some extent, and it will lay a foundation for the development of a mobile APP for TCM health management of T2DM
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