T-Cell Antigen Receptor-Induced Signal-Transduction Pathways. Activation and Function of Protein Kinases C in T Lymphocytes

Abstract

ContentsT-cell activation–Structure of the T-cell antigen receptor–Modular organisation of the T-cell antigen receptor–T-cell antigen receptor-coupled signaling pathways:Activation of protein-tyrosine kinase by the T-cell antigen receptor; Signal transduction in lymphoid cells involves several protein-tyrosine kinases in parallel; Regulation of T-cell antigen receptor signaling by the phosphoprotein phosphatase CD45–Consequences of T-cell antigen receptor-induced tyrosine phosphorylation:Activation of phosphoinositol-lipid-turnover pathways – Activation of phospholipase C-γ-1: p59fyn or p56lck?–G-protein motif of CD3-γ: relevance for signal transduction – Association of lipid kinase with the T-cell antigen receptor – Intracellular signaling by phospholipid metabolites and calcium: activation of protein kinase C–Protein kinase C isoenzymes – Heterogenity of protein kinase C and mode of activation – Phospholipid-derived mediators in activation of protein kinase C in T-cells – Role of phospholipase D metabolites in activation of protein kinase C – Polyunsaturated fatty acids and lysophosphatidylcholine as activators of protein kinase C – Potein kinase C and p21ras function in interdependent and distinct signaling pathways during T-cell activation – Raf-1 kinase: regulator or target of protein kinase C?– Summary and perspectives.