TCEANC2 rs10788972 and rs12046178 variants in the PARK10 region in Chinese Han patients with sporadic Parkinson's disease

Abstract

Parkinson's disease (PD) is the second most common chronic neuronal degeneration disorder with motor and nonmotor clinical features. The rs10788972 variant of the transcription elongation factor A (SII) N-terminal and central domain containing 2 (TCEANC2) gene in the PARK10 region was recently identified to be strongly related to sporadic PD in the American population. To evaluate whether the same variant is associated with sporadic PD in Chinese Han population, we researched 513 sporadic PD patients and 512 normal controls of Chinese Han ethnicity in Mainland China. No significant difference in genotypic and allelic distributions between patients and control groups for either rs10788972 (for genotypic distribution, χ2 = 0.412, p = 0.814, and for allelic distribution, χ2 = 0.280, p = 0.597) or its neighbor marker rs12046178 (for genotypic distribution, χ2 = 1.500, p = 0.472, and for allelic distribution, χ2 = 1.339, p = 0.247) was found. Our data suggest that neither variant is related to sporadic PD in Chinese Han population.