Abstract
TCDD was found to cause a significant rise in protein tyrosine kinase levels at an early stage of poisoning in rat liver membrane preparations. The results of sephadex G-150 column chromatographic analysis on rat hepatocyte membranes indicate that there are at least three tyrosine kinases of which activities increase as a consequence of TCDD treatment in vivo . The TCDD-evoked rise in such protein tyrosine kinase activity precedes the down-regulation of the EGF (epidermal growth factor) receptor in the plasma membrane in vivo .
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