Abstract
The purpose of this study is to determine the value of Tc-99m HMPAO SPECT in the diagnosis of the dementias. Tc-99m HMPAO was used with a 3-camera scanner to produce 5 sets of sectional images of the brain. Images were further processed using Statistical Parametric Mapping. Diagnosis was made by a physician blinded to the clinical diagnosis. Results in 73 subjects were compared with a neuropathologic study of the brain at autopsy. Data were analyzed for sensitivity, specificity, positive and negative predictive values and accuracy. These results are compared with several other studies performed with Tc-99m HMPAO SPECT with histopathologic correlation. This procedure is widely available and relatively inexpensive and may be of value in patients with dementias and problematic diagnoses. Further, a degree of differential diagnosis between Alzheimer's and Frontotemporal diseases may be effected. The study was approved by our Institutional Review Board.
Highlights
This is one of a continuing series [3–7] of reports on a group of patients studied with Tc-99m hexamethylpropyleneamine oxime (HMPAO, Mallinckrodt, Inc.) SPECT brain blood flow
SPECT brain blood flow imaging has the ability to detect active Alzheimer’s disease with approximately 90% accuracy
It can be postulated that this technique is capable of differential diagnosis between AD and the Frontotemporal dementias
Summary
The purpose of this study is to determine the value of Tc-99m HMPAO SPECT in the diagnosis of the dementias
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
