Abstract
In this new era of DNA sequencing and associated bioinformatics, in which a relatively large number of genes can be rapidly sequenced, it is now quite possible that most of the leading bacterial pathogens will be fully sequenced within the next five to ten years 1 Cole S.T. Barrell B.G. Novartis Found. Symp. 1998; 217: 160-172 Crossref PubMed Google Scholar . From the perspective of those of us working in the mycobacteria field, the completion of the genome of Mycobacterium tuberculosis H37Rv is probably one of the most important advances in our field since the identification of the bacillus a century ago 2 Cole S.T. et al. Nature. 1998; 393: 537-544 Crossref PubMed Scopus (6424) Google Scholar . This achievement has unleashed a veritable flood of information that will undoubtedly bear fruit in both drug discovery and the rational design of new vaccines.
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