Abstract
Two novel taxanes were identified from rooted cuttings of the Japanese yew, Taxus cuspidata Sieb. et Zucc. Their structures were characterized as taxa-4(20),11-dien-2α,5α-diacetate-14β-(2'S,3'R)-3'-hydroxy-2'-methylbutyrate-10-β-glucoside (1) and 2α,5α,9α,10β-tetraacetoxy-13α-(Z)-cinnamoyloxy-taxa-4(20),11-diene (2). In addition, metabolites 343 were also characterized in the same cuttings. Taxanes 316 as well as three non-taxane metabolites (1719) have not previously been reported in the needles, stems, seeds, or bark of the mature T. cuspidata plant, although they have been found in other yews. The known taxanes 2043 were also detected for the first time in the rooted cuttings of the Japanese yew. Key words: Taxus cuspidata, Taxacae, taxanes, rooted cuttings, metabolites.
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