Abstract
Naproxen is one of the most used drugs today. Therefore, it is important to develop new and simple methods for the determination of naproxen. The goal of this research is to develop a gas chromatography-mass spectrometry method for analyzing naproxen levels in rabbit plasma and apply this method to the pharmacokinetic study. The liquid-liquid extraction technique was used to prepare blood samples from rabbits. Separation of naproxen was achieved on an HP-5 MS column. The method’s calibration curve was plotted between 0.1 and 5.0 μg mL-1. The accuracy results were better than 2.18% and the precision results were less than 4.17% in rabbit plasma for naproxen. The method had recovery values >94.2% for all samples in rabbit plasma. In addition, the validated method was used to study naproxen pharmacokinetics in rabbits. The maximum naproxen plasma concentration is 42.1±4.243 μg mL-1. The duration to attain the greatest naproxen concentration and the area under the curve from (AUC0-16 h) were 1.50±0.196 h and 566.3±41.72 μg mL-1 h.
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