Taux d'interféron gamma au cours de la maladie périodique

Abstract

Aims. – To evaluate the levels of endogenous interferon-gamma (IFN-γ) in patients with familial Mediterranean fever (FMF). Materials and methods. – Plasma levels of IFN-γ were assayed in 29 FMF patients in attack-free period (mean age: 32, min–max: 17–48; male/female: 10:19), 18 FMF patients with acute FMF attack (mean age: 32, min–max: 19–50; male/female: 8:10), and 19 healthy controls (mean age: 31.94 ± 1.50, min–max: 23–42; male/female: 11:8). IFN-γ levels were also compared among colchicine treated and untreated groups. Results. – Median plasma IFN-γ levels were significantly higher in patients both with and without FMF attack than the control group ( P < 0.05). Moreover, plasma IFN-γ levels were higher in patients with acute FMF attack compared to patients in attack-free periods ( P < 0.05). Plasma levels of IFN-γ were comparable in colchicine treated and untreated groups. Conclusion. – Our results suggest that IFN-γ may contribute to the inflammatory cascade of FMF.