Abstract
Taurine transport was investigated in brush border membrane vesicles isolated from renal tubules of the winter flounder (Pseudopleuronectes americanus). Taurine uptake by the vesicles was greater in the presence of NaCl as compared to uptake in KCl. The Na+-dependent taurine transport was electrogenic and demonstrated tracer replacement and inhibition by β-alanine and HgCl2, indicating the presence of Na+-dependent, carrier-mediated taurine transport. In contrast to Na+-dependent taurine transport across the basolateral membrane, there was not a specific Cl− dependency for transport in the brush border membrane. No evidence was obtained for Na+-independent carrier-mediated taurine transport. The possible involvement of the brush border Na+-dependent transport system in the net secretion of taurine from blood to tubular lumen in vivo (Schrock et al. 1982) is discussed.
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