Abstract
Taurine protects against tissue damage in a variety of models involving inflammation, especially the lung1,2. The mechanism of taurine protection is not well understood but the ability of taurine to attenuate the toxic effects of HOCl/OCl- by formation of taurine chloramine (Tau-Cl) and its subsequent effects are thought to be important. Tau-Cl is formed by the action of the halide-dependent myeloperoxidase (MPO) system associated with neutrophils3,4.Considering the crucial role that alveolar macrophages play during pulmonary inflammatory events, we determined the effects of Tau-Cl on the production of NO, TNF-α, MCP-1, and MIP-2 in NR8383 cells. NR8383 cells are a cell line derived from rat alveolar macrophages.
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