Abstract
Taurine is a kind of endogenous free amino acid in tissue and a potent antioxidant agent its function may in part be to adjust calcium homeostasis in cells, anti-oxidative stress, anti-inflammatory and cell protector but little is known about the expression or the role of Taurine in the central nervous system. Stroke is the major cause of death and disability worldwide. Here, we investigated the role of Taurine in ischemic stroke as a potential neuroprotective using rat model of transient cerebral ischemia. Transient cerebral ischemia was induced by MCAO were performed on male Sprague-Dawley rats. TTC staining used to measurement of infarct volume in the brain and ELISA kits to assay cytokines. Our data suggested that Taurine reduced cerebral infarct size, decreased pro-inflammatory cytokines expression and produced lower level of ICAM-1. These results suggest that Taurine can be exerting significantly protective effect against brain ischemic injury through inhibiting pro-inflammatory cytokines and ICAM-1.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
