Abstract
Elevation of urinary taurine and creatine excretion occurs after whole-body irradiation. The source of the excessive creatinuria is thought to be disordered metabolism of creatine in skeletal muscle. The source of the increased taurinuria is not known. It may reflect increased oxidation of sulfur-containing precursors, or it may represent release from the free amino acid pool of injured tissue. Cells of skeletal muscle and the reticulo-endothelial system have a high taurine content. The present study demonstrates that similar increases in urinary creatine and taurine occur after drug-induced muscle necrosis and whole-body X-irradiation (800 R) in the rat. The excessive creatinuria is probably derived from cells of skeletal muscle in both instances. When values obtained from individual animals are plotted against each other, urine taurine and creatine excretion after the onset of plasmocid-induced skeletal muscle necrosis show a highly significant correlation (r = 0.71). After whole-body irradiation, howev...
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.