Abstract
Elevation of urinary taurine and creatine excretion occurs after whole-body irradiation. The source of the excessive creatinuria is thought to be disordered metabolism of creatine in skeletal muscle. The source of the increased taurinuria is not known. It may reflect increased oxidation of sulfur-containing precursors, or it may represent release from the free amino acid pool of injured tissue. Cells of skeletal muscle and the reticulo-endothelial system have a high taurine content. The present study demonstrates that similar increases in urinary creatine and taurine occur after drug-induced muscle necrosis and whole-body X-irradiation (800 R) in the rat. The excessive creatinuria is probably derived from cells of skeletal muscle in both instances. When values obtained from individual animals are plotted against each other, urine taurine and creatine excretion after the onset of plasmocid-induced skeletal muscle necrosis show a highly significant correlation (r = 0.71). After whole-body irradiation, howev...
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