Abstract
The responding pathway (process from agonist binding to channel opening) of taurine and β-alanine was investigated in Xenopus oocytes injected with mouse brain poly(A) + RNA. Responses to γ-aminobutyric acid (GABA), glycine, taurine and β-alanine were induced in oocytes injected with poly(A) + RNA extracted from 3 regions, cerebrum, cerebellum and brainstem of the mouse brain. From comparison, responses to these 4 inhibitory amino acids in each regional poly(A) + RNA-injected oocytes were categorized into at least 3 groups: (1) GABA, (2) glycine, and (3) taurine and β-alanine. No cross-desensitization was observed between GABA response and glycine response, but taurine and β-alanine responses cross-desensitized both the GABA and glycine responses. Taurine and β-alanine responses were partially inhibited by the GABA antagonist, bicuculline, and also by the glycine antagonist, strychnine. The results suggest that the taurine or the β-alanine response in the brain is caused through both the GABA receptor and the glycine receptor.
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