État des lieux sur l’hyperkaliémie chronique persistante en France : consensus d’experts par une approche Delphi

Abstract

IntroductionIn France, no consensus document on the management of persistent hyperkalaemia is currently available. Variability in clinical practices has been observed. MethodsA consensus statement on the definition and the management of persistent hyperkalaemia was developed by a Delphi panel of French nephrologists between December 2019 (26 voting participants among 40 invited panellists in first round) and June 2020 (20 voting participants among 26 panellists in second round). ResultsPersisting hyperkalaemia not controlled with current treatment strategies may be defined as the occurrence of two or more hyperkalaemia episodes within a year despite the administration of cation-exchange resins or loop diuretics during the same year. Some patient characteristics (diabetes, chronic kidney disease from stage 3B to stage 5 without dialysis, chronic heart failure) are associated with an increased risk of developing persistent hyperkalaemia. There is a medical need for the management of persistent hyperkalaemia in patients treated with renin-angiotensin-aldosterone system inhibitors that is not met by current treatment strategies (including available cation-exchange resins). ConclusionsThe panel expressed a need for new treatment strategies validated by clinical trials.