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Abstract
Seventeen-day-old rat pups received intraoral infusions of two novel flavors, coffee (0.625% w/v Sanka, decaffeinated) and saccharin (0.5% w/v), of which one (CS+) was paired with a 0.75% body weight, Lp. iiYection of 0.4 M LiCI, and the other (CS-) was presented alone. On the following day, two more infusion tests were conducted to determine intake of each flavor. Intake of the CS+ flavor was markedly suppressed, relative to that of the CS- flavor, although the magni tude ofthis effect depended on which flavor was designated CS+ and on the order in which CS+ and CS- were presented on the test day. These results indicate that preweanling rats are capa ble of discriminative taste aversion learning. This simple conditioning procedure should provide a useful method for studying the sensory development of the gustatory system and/or the de velopmental psychobiology of learning and memory.
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