Task-related connectivity of decision points during spatial navigation in a schematic map.

Abstract

Successful navigation is largely dependent on the ability to make correct decisions at navigational decision points. However, the interaction between the brain regions associated with the navigational decision point in a schematic map is unclear. In this study, we adopted a 2D subway paradigm to study the neural basis underlying decision points. Twenty-eight subjects performed a spatial navigation task using a subway map during fMRI scanning. We adopted a voxel-wise general linear model (GLM) approach and found four brain regions, the left hippocampus (HIP), left parahippocampal gyrus (PHG), left ventromedial prefrontal cortex (vmPFC), and right retrosplenial cortex (RSC), activated at a navigational decision point in a schematic map. Using a psychophysiological interactions (PPI) method, we found that (1) both the left vmPFC and right HIP interacted cooperatively with the right RSC, and (2) the left HIP and the left vmPFC interacted cooperatively at the decision point. These findings may be helpful for revealing the neural mechanisms underlying decision points in a schematic map during spatial navigation.