Abstract
Understanding how the living human brain functions requires sophisticated in vivo neuroimaging technologies to characterise the complexity of neuroanatomy, neural function, and brain metabolism. Fluorodeoxyglucose positron emission tomography (FDG-PET) studies of human brain function have historically been limited in their capacity to measure dynamic neural activity. Simultaneous [18 F]-FDG-PET and functional magnetic resonance imaging (fMRI) with FDG infusion protocols enable examination of dynamic changes in cerebral glucose metabolism simultaneously with dynamic changes in blood oxygenation. The Monash vis-fPET-fMRI dataset is a simultaneously acquired FDG-fPET/BOLD-fMRI dataset acquired from n = 10 healthy adults (18–49 yrs) whilst they viewed a flickering checkerboard task. The dataset contains both raw (unprocessed) images and source data organized according to the BIDS specification. The source data includes PET listmode, normalization, sinogram and physiology data. Here, the technical feasibility of using opensource frameworks to reconstruct the PET listmode data is demonstrated. The dataset has significant re-use value for the development of new processing pipelines, signal optimisation methods, and to formulate new hypotheses concerning the relationship between neuronal glucose uptake and cerebral haemodynamics.
Highlights
Background & SummaryThe enhanced abilities of the human brain to plan complex behaviour, make decisions, and process emotional and social contexts comes with heavy energy requirements
Understanding how the living human brain functions requires sophisticated in vivo neuroimaging technologies to characterise the complexity of neuroanatomy, neural function and brain metabolism
The technological developments that have led to simultaneous positron emission tomography (PET) – magnetic resonance imaging (MR)[4] has made it possible to simultaneously measure changes in blood oxygenation and glucose metabolism using simultaneous Fluorodeoxyglucose positron emission tomography (FDG-PET)/BOLD-functional magnetic resonance imaging (fMRI) ([18 F]-fluorodeoxyglucose PET - blood oxygenation level dependent functional MRI)
Summary
Background & SummaryThe enhanced abilities of the human brain to plan complex behaviour, make decisions, and process emotional and social contexts comes with heavy energy requirements. The dataset comprises unreconstructed fPET list-mode sinogram data, as well as PET image data reconstructed into 1-min time intervals.
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