Abstract
A series of biologically active polysubstituted dihydropyrrol-2-ones are prepared via a one-pot four-component reaction of structurally diverse dialkyl acetylenedicarboxylate, formaldehyde, and amines (aromatic and aliphatic) using a catalytic amount of tartaric acid as a naturally green, mild di-functional Bronsted acid catalyst at ambient temperature. The use of tartaric acid as an inexpensive catalyst makes this procedure eco-friendlier and also one-pot, easily separated from the reaction mixture, good to high yields, short reaction times, simple operational procedures, and highly efficient that are the added advantages of the present methodology.
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