Abstract
External polyamines have been a valuable tool as pharmacological markers of Ca2+-permeable AMPARs (CP-AMPARs). However, recent work in the developing retina has revealed a population of CP-AMPARs which are unexpectedly insensitive to external polyamines. Because TARPs attenuate internal polyamine block, we hypothesized that TARP association with CP-AMPARs would also diminish external polyamine block, and thus display the phenotype observed in the retina. Similarly, TARPs have also been reported to reduce the potency of another useful pharmacological tool: the competitive antagonist CNQX.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
