Targets specific to certain Treg cell types in the TME of pancreatic cancer

Abstract

The increased content of Treg cells in the pancreatic cancer TME shows the development of pancreatic cancer is largely influenced by treg cells. Regulatory T cells (Treg) have a powerful immune suppression function, under normal circumstances, have the function of maintaining autoimmune tolerance. When Treg cells expressing abnormally in tumor tissue, they can inhibit normal anti-tumor immune response, accelerate the immune escape in tumor cells, promote tumor growth. Meanwhile, Treg can also inhibit tumor growth through anti-inflammatory and anti-angiogenesis routes. Blind killing and inhibition of Treg will destroy the maintenance of the body's self-immune tolerance and cause some damage. In this paper, the duality of Treg cells is summarized through two aspects, including the summary analysis of specific targets on different types of Treg cells in TME to find the targets that can specifically kill immunosuppressive Treg cells; discuss the interactions between Treg cells and their surrounding cells, and their relationship with the duality of Treg cells, in order to provide the basis for reducing damage and optimizing immunotherapy during immunotherapy.