Targeting Transient Receptor Potential Channels in Cardiometabolic Diseases and Myocardial Ischemia Reperfusion Injury.

Abstract

Cardiovascular disease is still the most frequent cause of death in both developed and developing countries while metabolic syndrome and myocardial ischemia reperfusion (I/R) injury are the common risk factors responsible for the impaired cardiac function. Transient receptor potential (TRP) channels are non-selective cation channels, that sense a broad range of stimuli from physical conditions such as stretch, to chemicals including capsaicin. The diverse studies have revealed multifunctional roles of TRP channels in the physiological conditions and various diseases while some members of TRP channel superfamily are demonstrated to participate in the pathophysiology of cardiometabolic diseases and myocardial ischemia reperfusion injury. Here we discuss the roles of TRP channels in myocardial ischemia reperfusion and cardiometabolic diseases and their potential use in treating these diseases. Regulation of TRP channels facilitates the control of metabolic syndrome such as obesity, diabetes mellitus, hypertension, and atherosclerosis. This review presents an overview of our current knowledge regarding the physiological functions of TRP channels in the metabolic and cardiovascular systems and their contributions to cardiometabolic diseases and I/R injury. On the basis of these discoveries, the therapeutic potential of targeting novel TRP channels can be proposed for the treatment of cardiometabolic diseases and I/R injury.