Targeting Survivin’s Co-Conspirators: Do Alternative Methods of Trapping Survivin in the Nucleus Have Potential in Triple-Negative Breast Cancer Therapy?

Abstract

Future OncologyVol. 8, No. 8 EditorialTargeting survivin’s co-conspirators: do alternative methods of trapping survivin in the nucleus have potential in triple-negative breast cancer therapy?Michael P Holloway & Rachel A AlturaMichael P HollowayThe Warren Alpert Medical School at Brown University & Rhode Island Hospital, Providence, RI, USASearch for more papers by this author & Rachel A Altura* Author for correspondenceDepartment of Pediatrics, The Warren Alpert Medical School at Brown University & Rhode Island Hospital, 593 Eddy Street, MPS 126, Providence, RI 02903, USA. Search for more papers by this authorEmail the corresponding author at rachel_altura@brown.eduPublished Online:15 Aug 2012https://doi.org/10.2217/fon.12.77AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: breast cancerCRM1HDAC6survivinReferences1 Foulkes WD, Smith IE, Reis-Filho JS. Triple-negative breast cancer. N. Engl. J. Med.363(20),1938–1948 (2010).Crossref, Medline, CAS, Google Scholar2 Badve S, Dabbs DJ, Schnitt SJ et al. Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists. Mod. Pathol.24(2),157–167 (2011).Crossref, Medline, Google Scholar3 Altieri DC. Survivin, cancer networks and pathway-directed drug discovery. Nat. Rev. Cancer8(1),61–70 (2008).Crossref, Medline, CAS, Google Scholar4 Colnaghi R, Connell CM, Barrett RM, Wheatley SP. 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Drugs19(9),1049–1066 (2010).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetailsCited ByTargeting Survivin in Cancer: Novel Drug Development Approaches18 August 2013 | BioDrugs, Vol. 28, No. 1Association of survivin splice variants with prognosis and treatment of breast cancerWorld Journal of Clinical Oncology, Vol. 5, No. 5 Vol. 8, No. 8 eToC Sign up Follow us on social media for the latest updates Metrics Downloaded 208 times History Published online 15 August 2012 Published in print August 2012 Information© Future Medicine LtdKeywordsbreast cancerCRM1HDAC6survivinFinancial & competing interests disclosureFunding for the work described here was supported by the National Institute of General Medical Sciences of the NIH under award number P20GM103421. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download