Abstract
The eukaryotic RNA exosome is an essential and conserved protein complex that can degrade or process RNA substrates in the 3'-to-5' direction. Since its discovery nearly two decades ago, studies have focused on determining how the exosome, along with associated cofactors, achieves the demanding task of targeting particular RNAs for degradation and/or processing in both the nucleus and cytoplasm. In this review, we highlight recent advances that have illuminated roles for the RNA exosome and its cofactors in specific biological pathways, alongside studies that attempted to dissect these activities through structural and biochemical characterization of nuclear and cytoplasmic RNA exosome complexes.
Highlights
Nuclear and cytoplasmic forms of the RNA exosome are defined by unique subunit compositions that interact with distinct cofactors in these subcellular compartments (Table 1)
Redundant with cytoplasmic 5′-to-3′ decay pathways (Anderson and Parker 1998), Exo10Dis3 contributes to translation-dependent mRNA surveillance pathways such as nonstop decay (NSD), nonsense-mediated decay (NMD), and no-go decay (NGD)
While dis3 alleles that disrupt its endo activity bear few phenotypic defects, mutations that disrupt its exo activity result in slow growth, and mutations that disrupt both activities result in synthetic growth defects or inviability (Lebreton et al 2008)
Summary
Ski Rrp Rrp Rrp, Ski Rrp Mtr Rrp Rrp Rrp, PM/Scl-75 Rrp, PM/Scl-100 Dis, Rrp. This review focuses on recent developments pertaining to the diverse biological functions of the exosome and our current understanding of how its structure and biochemical activities enable it to achieve these functions. This will include a brief survey of newly uncovered biological roles for the RNA exosome as well as an overview of our current knowledge for the structural basis of interactions between exosomes, RNA substrates, and cofactors that influence its processing and/or degradation activities
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
