Abstract
RET (rearranged during transfection) is a receptor tyrosine kinase overexpressed in a subset of oestrogen receptor (ER)-positive breast cancers whose expression is regulated by ER signalling. The article from the Hynes group has reported for the first time that RET expression can also be regulated by the inflammatory cytokine IL-6. Importantly, RET and IL-6 interact at a functional level to control migration and the metastatic potential of ER-positive breast cancer cells, in a process that is mediated by FAK activation. Further, targeting RET with receptor tyrosine kinase inhibitors was reported to be more effective than endocrine therapies in impairing metastatic dissemination in vivo, thereby indicating a level of RET regulation that is independent of ER.
Highlights
Many breast cancers are characterised by amplification or overexpression of receptor tyrosine kinases such as ErbB2/human epidermal growth factor receptor 2 (HER2), epidermal growth factor receptor, insulin-like growth factor receptor and fibroblast growth factor receptor 1 that can drive tumour growth
Rearranged during transfection (RET) and IL-6 interact at a functional level to control migration and the metastatic potential of Oestrogen receptor (ER)-positive breast cancer cells, in a process that is mediated by Focal adhesion kinase (FAK) activation
Targeting RET with receptor tyrosine kinase inhibitors was reported to be more effective than endocrine therapies in impairing metastatic dissemination in vivo, thereby indicating a level of RET regulation that is independent of ER
Summary
Many breast cancers are characterised by amplification or overexpression of receptor tyrosine kinases such as ErbB2/human epidermal growth factor receptor 2 (HER2), epidermal growth factor receptor, insulin-like growth factor receptor and fibroblast growth factor receptor 1 that can drive tumour growth. RET and IL-6 interact at a functional level to control migration and the metastatic potential of ER-positive breast cancer cells, in a process that is mediated by FAK activation.
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