Abstract
Cardio-cerebrovascular disease (CCVD) has become the leading cause of human mortality with the coming acceleration of global population aging. Atherosclerosis is among the most common pathological changes in CCVDs. It is also a multifactorial disorder; oxidative stress caused by excessive production of reactive oxygen species (ROS) has become an important mechanism of atherosclerosis. Chinese herbal medicine (CHM) is a major type of natural medicine that has made great contributions to human health. CHMs are increasingly used in the auxiliary clinical treatment of atherosclerosis. Although their mechanism of action is unclear, CHMs can exert a variety of antiatherosclerosis effects by regulating intracellular ROS. In this review, we discussed the mechanism of ROS regulation in atherosclerosis and analyzed the role of CHMs in the treatment of atherosclerosis via ROS.
Highlights
Cardio-cerebrovascular diseases (CCVD) refer to the ischemic and hemorrhagic diseases of the heart, brain, and body, caused by hyperlipidemia, blood viscosity, atherosclerosis, hypertension, among other factors [1]
Through the literature research on atherosclerosis, we found that atherosclerosis is the pathological basis of many diseases and can damage many organs, especially the heart and brain [116, 117]
Chinese herbal medicine (CHM) have the characteristics of multiple components and multiple targets [119], which can protect multiple organs caused by atherosclerosis
Summary
Cardio-cerebrovascular diseases (CCVD) refer to the ischemic and hemorrhagic diseases of the heart, brain, and body, caused by hyperlipidemia, blood viscosity, atherosclerosis, hypertension, among other factors [1]. It is widely defined that excessive ROS production outpacing the usable antioxidant systems results in oxidative stress [8], which can promote and increase the occurrence and development of atherosclerosis [9, 10]. Probucol was first listed as a lipid-lowering drug in the United States in 1977 and has been recognized as the most promising and effective first-line antioxidant in the treatment of atherosclerosis [13]. Active compounds extracted from CHMs have therapeutic effects on oxidative stress in vivo and vitro, providing an approach for the development of antiatherosclerosis drugs. Accumulating evidence showed that welldesigned clinical trials in the prevention and treatment of CCVDs based on the antioxidative therapy by CHMs acquire certain efficacy [18, 19].
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