Targeting of Calcitriol to Inflammatory Breast Cancer Tumors and Metastasis In Vitro and In Vivo

Rachel J Schaefer,Rebecca Russell

doi:10.4172/bso.1000104

Abstract

Targeting of Calcitriol to Inflammatory Breast Cancer Tumors and Metastasis In Vitro and In Vivo

Highlights

With its aggressive nature and high mortality rate, Inflammatory Breast Cancer (IBC) is arguably the most deadly form of breast cancer [1]
To target calcitriol to IBC cells, calcitriol bound QDs (CalQDs) were conjugated with two clones of anti-human mouse MUC1 antibodies, SM3 and HMPV
First we examined the uptake of the particles to confirm their ability to enter SUM149 cells, an IBC cell line and C2C12 cells as a control cell line

Summary

Introduction

With its aggressive nature and high mortality rate, Inflammatory Breast Cancer (IBC) is arguably the most deadly form of breast cancer [1]. IBC is molecularly unique from other forms of breast cancer, having expression trends opposite that of conventional breast cancers [3]. IBC tumors are highly metastatic, invading the dermal lymphatic vessels of the skin overlying the breast [1,2,3]. The presence of tumor emboli in the dermal lymphatic vessels is a hallmark of IBC and thought to contribute to the rapid and prolific spread of the disease [2,3].

Methods

Results

Conclusion