Abstract
Targeting leukemia stem cells:<i>in vitro</i>veritas?
Highlights
In the past two decades it has become increasingly recognized that, in several types of cancer, only a fraction of the neoplastic cells is capable of propagating tumors upon transplantation whereas the majority of tumor cells lacks this capacity
This obstacle may be circumvented using experimental models of myeloid leukemogenesis based on the retroor lentiviral transduction of normal hematopoietic stem and progenitor cells (HSPCs) with leukemia-associated oncogenes
The enforced expression of these oncogenes, alone or in combination, confers on the transduced cells features similar to those of leukemia-initiating cells (L-ICs), thereby generating transformed cell lines enriched in leukemia stem-like cells
Summary
In the past two decades it has become increasingly recognized that, in several types of cancer, only a fraction of the neoplastic cells is capable of propagating tumors upon transplantation whereas the majority of tumor cells lacks this capacity. The therapeutic challenges posed by this model of leukemogenesis have spurred the active quest for novel strategies for the eradication of the LSC compartment.
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