Abstract
One major hallmark of atopic dermatitis (AD) is the elevated level of total serum IgE, which has been reported to be partly of the autoreactive type in a subset of patients. Immunoadsorption (IA) has been successfully applied in various classical autoantibody-mediated diseases such as pemphigus. Recent reports proposed the use of IA also for patients with severe AD and high total serum IgE levels. In this mini-review, we summarize the current knowledge about this novel treatment approach for AD and briefly discuss the so far incompletely known role of autoreactive IgE as potential target of IA therapy in this common inflammatory skin disorder.
Highlights
Targeting ige Antibodies by immunoadsorption in Atopic DermatitisMichael Kasperkiewicz1*, Enno Schmidt[1,2], Ralf J
Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, pruritic skin disease affecting 2–20% of the general population, which can considerably affect the patient’s quality of life
We reported two cases of S. aureus septicemia, one occurring after panimmunoglobulin IA and the other following IgE-selective IA, both performed by a central venous catheter (4, 9)
Summary
Michael Kasperkiewicz1*, Enno Schmidt[1,2], Ralf J. Targeting IgE Antibodies by Immunoadsorption in Atopic Dermatitis. One major hallmark of atopic dermatitis (AD) is the elevated level of total serum IgE, which has been reported to be partly of the autoreactive type in a subset of patients. Immunoadsorption (IA) has been successfully applied in various classical autoantibody-mediated diseases such as pemphigus. Recent reports proposed the use of IA for patients with severe AD and high total serum IgE levels. In this mini-review, we summarize the current knowledge about this novel treatment approach for AD and briefly discuss the so far incompletely known role of autoreactive IgE as potential target of IA therapy in this common inflammatory skin disorder
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