Abstract
Targeting Host Cell Factors for Development of Antiviral therapeutics
Highlights
As an obligate intracellular parasite, virus has to rely on host cell machinery for its effective replication (Beaud, 1995; Ludwig et al, 2006; Saito, 2006)
Accumulating evidences suggest involvement of various host cell factors at different steps of virus replication cycle and each essential steps of replication cycle is considered as a potential site for antiviral intervention (Borgeling et al, 2014; Dierkes et al, 2014)
Neuraminidase inhibitors came with great success, but by 2009, resistant mutants have been reported in both seasonal and pandemic H1N1 suggesting an alternative strategy to be design that do not have a tendency to induce drug resistance in viruses due to preexisting selection pressure
Summary
As an obligate intracellular parasite, virus has to rely on host cell machinery for its effective replication (Beaud, 1995; Ludwig et al, 2006; Saito, 2006). Virus encoded protein targets are attractive but can lead to selection of drug resistant variants over a period of time due to mutations (Poland et al, 2009). Most of the currently available antiviral agents target viral components; repeated use of which leads to emergence of drug resistant virus variants due to mutations (Bloom et al, 2010; Fry and Gubareva, 2012; Hamelin et al, 2010; Hayden, 2009; Hayden, 2006; Hayden and de Jong, 2011; Hayden and Hay, 1992; Ismail et al, 2012; Pawlotsky, 2012; Ujike et al, 2010). The cellular factors that are required for virus replication but at the same time are dispensable for host cell metabolism may be such targets for antiviral interventions as virus cannot replace missing cellular functions by mutations (Edinger et al, 2014; Ehrhardt et al, 2010; Eierhoff et al, 2009; Fry and Gubareva, 2012; Kumar et al, 2011b; Ludwig, 2011; Ludwig et al, 2006; Pleschka et al, 2001)
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