Targeting cytotoxicity and tubulin polymerization by metal-carbene complexes on a purine tautomer platform.

Abstract

This communication describes the synthesis, structural investigation and tubulin binding of purine rare imino-tautomer based Ag(i) and Hg(ii)-carbene complexes. These complexes exhibit cytotoxicity through tubulin interaction by binding to a site close to the GTP binding site.